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Heart rate variability and Omega-3 Index in euthymic patients with bipolar disorders

A Voggt1, M Berger2, M Obermeier3

  • 1Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany.

European Psychiatry : the Journal of the Association of European Psychiatrists
|January 4, 2015
PubMed

Insights

Patients with bipolar disorder have significantly lower heart rate variability (SDNN) compared to healthy individuals. This difference is not explained by Omega-3 Index levels, suggesting SDNN as a potential tool for cardiovascular risk assessment in bipolar disorder.

Area of Science:

  • Cardiology
  • Psychiatry
  • Biomarkers

Background:

  • Affective disorders increase cardiovascular disease (CVD) risk, partly independent of medication.
  • Reduced heart rate variability (SDNN) and low Omega-3 Index are linked to higher mortality post-myocardial infarction.

Purpose of the Study:

  • To investigate heart rate variability (SDNN) and Omega-3 Index in euthymic patients with bipolar disorder.
  • To explore potential cardiovascular risk markers in this population.

Main Methods:

  • Assessed SDNN and Omega-3 Index in 90 euthymic bipolar disorder patients and 62 healthy controls.
  • Measured SDNN via electrocardiography under resting conditions.
  • Controlled for age, sex, BMI, smoking, alcohol, and caffeine consumption.

Main Results:

  • Bipolar disorder patients exhibited significantly lower SDNN (35.4 msec) than controls (60.7 msec).
  • No significant difference in Omega-3 Index was observed between groups.
  • Group membership and age were significant predictors of SDNN.

Conclusions:

  • SDNN may be a valuable tool for assessing cardiovascular disease risk in euthymic bipolar disorder patients.
  • The observed difference in SDNN is not attributable to variations in Omega-3 Index levels.
Abstract

Keywords:
Bipolar disorderCardiovascular diseaseHeart rate variabilityOmega-3 Index

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