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Heart rate variability and Omega-3 Index in euthymic patients with bipolar disorders.
A Voggt1, M Berger2, M Obermeier3
1Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany.
Summary
Patients with bipolar disorder have significantly lower heart rate variability (SDNN) compared to healthy individuals. This difference is not explained by Omega-3 Index levels, suggesting SDNN as a potential tool for cardiovascular risk assessment in bipolar disorder.
Area of Science:
- Cardiology
- Psychiatry
- Biomarkers
Background:
- Affective disorders increase cardiovascular disease (CVD) risk, partly independent of medication.
- Reduced heart rate variability (SDNN) and low Omega-3 Index are linked to higher mortality post-myocardial infarction.
Purpose of the Study:
- To investigate heart rate variability (SDNN) and Omega-3 Index in euthymic patients with bipolar disorder.
- To explore potential cardiovascular risk markers in this population.
Main Methods:
- Assessed SDNN and Omega-3 Index in 90 euthymic bipolar disorder patients and 62 healthy controls.
- Measured SDNN via electrocardiography under resting conditions.
- Controlled for age, sex, BMI, smoking, alcohol, and caffeine consumption.
Main Results:
- Bipolar disorder patients exhibited significantly lower SDNN (35.4 msec) than controls (60.7 msec).
- No significant difference in Omega-3 Index was observed between groups.
- Group membership and age were significant predictors of SDNN.
Conclusions:
- SDNN may be a valuable tool for assessing cardiovascular disease risk in euthymic bipolar disorder patients.
- The observed difference in SDNN is not attributable to variations in Omega-3 Index levels.
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