Related Experiment Video
Updated: Apr 19, 2026
06:08
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
2.6K
[Targeted therapy in thyroid cancer: Towards a treatment card]
S Lkhoyaali1, S Benhmida1, M Ait Elhaj1
1Service d'oncologie médicale, institut national d'oncologie Moulay-Abdellah, rue Lamfadel-Cherkaoui Rabat Institut, BP 6527, 10000 Rabat, Maroc.
Pathologie-Biologie
|January 4, 2015
Summary
Thyroid cancer treatment is evolving. New targeted therapies show promise for advanced, refractory cases by targeting specific molecular mutations.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Thyroid cancer, though uncommon, presents challenges in advanced stages where conventional treatments like chemotherapy, surgery, and iodine therapy are ineffective.
- Recent advancements have deepened the understanding of thyroid cancer's molecular underpinnings and therapeutic targets.
Purpose:
- To review the oncogenetic characteristics of thyroid carcinoma.
- To explore novel targeted therapies for patients with thyroid cancer refractory to standard treatments.
Summary:
- Chemotherapy offers limited efficacy in advanced thyroid cancer.
- Targeted therapies, including motesanib, axitinib, sunitinib, pazopanib, vandetanib, cabozotinib, and sorafenib, are emerging for metastatic disease.
- These therapies target key molecular alterations such as RET, BRAF, and RAS mutations.
Impact:
- Provides an overview of current targeted treatment options for refractory thyroid cancer.
- Highlights the importance of molecular profiling in guiding therapeutic decisions.
- Informs clinicians and researchers about the latest advancements in thyroid cancer therapy.
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