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[Targeted therapy in thyroid cancer: Towards a treatment card]

S Lkhoyaali1, S Benhmida1, M Ait Elhaj1

  • 1Service d'oncologie médicale, institut national d'oncologie Moulay-Abdellah, rue Lamfadel-Cherkaoui Rabat Institut, BP 6527, 10000 Rabat, Maroc.

Pathologie-Biologie
|January 4, 2015
PubMed

Insights

Thyroid cancer treatment is evolving. New targeted therapies show promise for advanced, refractory cases by targeting specific molecular mutations.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Thyroid cancer, though uncommon, presents challenges in advanced stages where conventional treatments like chemotherapy, surgery, and iodine therapy are ineffective.
  • Recent advancements have deepened the understanding of thyroid cancer's molecular underpinnings and therapeutic targets.

Purpose:

  • To review the oncogenetic characteristics of thyroid carcinoma.
  • To explore novel targeted therapies for patients with thyroid cancer refractory to standard treatments.

Summary:

  • Chemotherapy offers limited efficacy in advanced thyroid cancer.
  • Targeted therapies, including motesanib, axitinib, sunitinib, pazopanib, vandetanib, cabozotinib, and sorafenib, are emerging for metastatic disease.
  • These therapies target key molecular alterations such as RET, BRAF, and RAS mutations.

Impact:

  • Provides an overview of current targeted treatment options for refractory thyroid cancer.
  • Highlights the importance of molecular profiling in guiding therapeutic decisions.
  • Informs clinicians and researchers about the latest advancements in thyroid cancer therapy.
Keywords:
Biologie moléculaireCancer de la thyroïdeMolecular biologyTargeted therapyThyroid cancerThérapies ciblées

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