A risk of digestive tract neoplasms susceptibility in miR-146a and miR-196a2

Genome-wide association studies have identified many genes associated with digestive tract neoplasms. However, the published findings have been conflicting. The aim of our study was to evaluate the involvement of two polymorphisms (miR-146a rs2910164, miR-196a2 rs11614913) in digestive tract neoplasms risk and explore how miR-146a and miR-196a2 influence this risk. Systemic research of the PubMed, EBSCO, CBM and VIP databases was performed. The software STATA 12.0 was used to calculate odd ratios and 95% confidence intervals. There were 14 studies (6,053 cases and 6,527 controls) available for rs2910164 and 15 studies (5,648 cases and 6,607 controls) involved in rs11614913. Rs2910164G>C was statistically significantly associated with digestive tract neoplasms (OR 1.134, 95% CI 1.076-1.194, P < 0.001). In the subgroup analysis by ethnicity, significant association was observed in Asian individuals (OR 1.145, 95% CI 1.084-1.209, P < 0.001). We found a correlation between rs11614913 and only colorectal cancer (OR 1.325, 95% CI 1.102-1.594, P = 0.003). This study suggested that digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants.