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14-3-3ζ regulates immune response through Stat3 signaling in oral squamous cell carcinoma

Xinguang Han1, Yongfu Han1, Huifeng Jiao1

  • 1Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

Molecules and Cells
|March 11, 2015
PubMed

Insights

14-3-3ζ protein is overexpressed in oral squamous cell carcinoma (OSCC), promoting tumor inflammation and immune evasion. This protein regulates immune cell responses and inflammation via Stat3 signaling in OSCC.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Ectopic 14-3-3ζ expression is observed in multiple cancers.
  • The role of 14-3-3ζ in tumor-immune interactions remains unexplored.

Purpose of the Study:

  • Investigate 14-3-3ζ's role in modulating tumor inflammation.
  • Determine 14-3-3ζ's involvement in immune recognition evasion in oral squamous cell carcinoma (OSCC).

Main Methods:

  • Analyzed 14-3-3ζ expression in OSCC cell lines and tissues.
  • Performed 14-3-3ζ knockdown and introduction experiments.
  • Assessed cytokine expression and immune cell responses.
  • Investigated the interaction between 14-3-3ζ and Stat3 signaling.

Main Results:

  • 14-3-3ζ is overexpressed in OSCC.
  • Knockdown of 14-3-3ζ up-regulated inflammatory cytokines in OSCC cells.
  • 14-3-3ζ introduction attenuated cytokine expression in normal cells.
  • 14-3-3ζ affected peritoneal macrophages, dendritic cells, and T cells.
  • Stat3 directly interacts with 14-3-3ζ, mediating its effects on inflammation.

Conclusions:

  • 14-3-3ζ plays a significant role in regulating tumor inflammation in OSCC.
  • 14-3-3ζ contributes to immune evasion in OSCC.
  • Stat3 signaling is a key pathway through which 14-3-3ζ influences tumor inflammation and immune response.
Keywords:
14-3-3ζStat3immune responseoral squamous cell carcinomatumor inflammation

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