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Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells
Published on: May 9, 2011
Pathobiology of ovarian carcinomas
Mojgan Devouassoux-Shisheboran1, Catherine Genestie
1Department of Pathology, Hôpital de la Croix Rousse, 69317 Lyon Cedex 04, France. catherine.genestie@gustaveroussy.fr.
Abstract:
Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.
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