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Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro
K E Boulukos1, P Pognonec, B Rabault
1Institut National de la Santé de la Recherche Medicale U186/Centre National de la Recherche Scientifique UA 041160, Institut Pasteur, Lille, France.
Molecular and Cellular Biology
|December 1, 1989
Abstract:
Ets1 and Ets2 are nuclear phosphoproteins which bind to DNA in vitro and share two domains of strong identity. Deletion analyses of each of these conserved regions in Ets1 demonstrated that integrity of the carboxy-terminal domain, also conserved in the more distantly related elk and erg gene products, is essential for both nuclear targeting and DNA-binding activity in vitro.