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Fatigue in psoriasis: a phenomenon to be explored.
I M Skoie1, T Ternowitz1, G Jonsson2
1Department of Dermatology, Stavanger University Hospital, Stavanger, Norway.
The British Journal of Dermatology
|January 6, 2015
Summary
Chronic fatigue significantly impacts patients with inflammatory diseases, affecting daily life and social functions. Research suggests a link between fatigue, the innate immune system, and oxidative stress, particularly in dermatological conditions like psoriasis.
Area of Science:
- Immunology
- Dermatology
- Pathophysiology
Background:
- Fatigue is a major debilitating symptom in chronic inflammatory diseases, impacting physical and social functioning.
- Psychological and somatic factors influence fatigue, but its underlying mechanisms remain largely unknown.
- Few studies address fatigue in dermatological diseases, often focusing on psoriatic arthritis.
Purpose of the Study:
- To define and explain chronic fatigue.
- To present hypothetical biological mechanisms of fatigue, emphasizing innate immunity and oxidative stress.
- To review clinical studies on psoriasis and fatigue.
Main Methods:
- Literature review of fatigue in chronic inflammatory and dermatological diseases.
- Exploration of biological mechanisms including innate immune activation and oxidative stress.
- Synthesis of findings from clinical studies on psoriasis and fatigue.
Main Results:
- Fatigue is a significant, underestimated issue in dermatology, particularly in psoriasis.
- Evidence suggests a genetic and molecular basis for fatigue linked to innate immunity and cellular stress.
- Biological mechanisms may involve innate immune system activation and oxidative stress.
Conclusions:
- Fatigue warrants greater attention within the dermatological community.
- Understanding the biological underpinnings of fatigue is crucial for effective management.
- Further research into psoriasis and fatigue is needed.
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