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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Multiple clustered dermatofibroma presenting in a segmental distribution.

Friyana K Bhabha1, Jill Magee2, Su Yuen Ng3

  • 1Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

The Australasian Journal of Dermatology
|January 6, 2015
PubMed
Summary
This summary is machine-generated.

Multiple clustered dermatofibromas are rare, presenting as plaques of numerous lesions. This report details a unique case of multiple clustered dermatofibroma in a 16-year-old boy with a segmental distribution, a presentation not previously documented.

Keywords:
CD34 positivityFactor 13a positivitybenign fibrous histiocytomamultiple clustered dermatofibromasegmental distribution

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Area of Science:

  • Dermatology
  • Rare Diseases
  • Clinical Case Reports

Background:

  • Multiple dermatofibromas, defined as over fifteen lesions, represent a rare cutaneous condition.
  • Multiple clustered dermatofibroma is a specific subtype characterized by a well-demarcated plaque of individual dermatofibromas.

Observation:

  • A 16-year-old male presented with numerous dermatofibromas.
  • The lesions exhibited a distinct clustered morphology.
  • The distribution of the dermatofibromas followed a segmental pattern.

Findings:

  • The patient was diagnosed with multiple clustered dermatofibroma.
  • The segmental distribution of this condition in a pediatric patient is a novel observation.

Implications:

  • This case expands the known clinical presentations of multiple clustered dermatofibromas.
  • Highlights the importance of recognizing rare dermatological variants in adolescent patients.
  • Suggests further investigation into potential genetic or developmental factors in segmental dermatofibroma