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Related Experiment Videos

Viral proteins containing the purine NTP-binding sequence pattern.

A E Gorbalenya1, E V Koonin

  • 1Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow.

Nucleic Acids Research
|November 11, 1989
PubMed
Summary
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Viral proteins with a specific NTP-binding pattern are widespread and non-randomly distributed. These conserved viral proteins likely function as NTPases in critical processes like DNA/RNA replication and repair.

Area of Science:

  • Virology
  • Molecular Biology
  • Bioinformatics

Background:

  • Viral proteins often possess conserved sequence patterns indicative of specific functions.
  • The NTP-binding sequence pattern is crucial for many enzymatic activities.
  • Understanding the distribution and function of such patterns in viral proteins is key to deciphering viral mechanisms.

Purpose of the Study:

  • To compile and analyze viral proteins containing the NTP-binding sequence pattern.
  • To assess the functional significance and evolutionary conservation of this pattern in viral proteins.
  • To identify viral protein families and superfamilies associated with NTP-binding.

Main Methods:

  • Sequence pattern identification and compilation.
  • Bioinformatic analysis of protein sequence distributions across the viral kingdom.

Related Experiment Videos

  • Sequence comparisons to delineate protein families and superfamilies.
  • Review of existing biochemical evidence.

    • Main Results:

    • A significant compilation of viral proteins exhibiting the NTP-binding sequence pattern was generated.
    • The distribution of these proteins within the viral kingdom was found to be non-random.
    • Several families and superfamilies of viral NTP-binding proteins were identified, with some linked to cellular protein superfamilies.
    • Biochemical data support the conserved nature of the pattern in viral NTPases.

    Conclusions:

    • The evolutionarily conserved NTP-binding pattern in viral proteins suggests a common functional role.
    • These viral NTPases are likely involved in essential processes such as nucleic acid replication, transcription, repair, translation, DNA packaging, and dNTP generation.