Transition Metals Catalyzed Element-Cyano Bonds Activations.
1Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA ; Department of Chemistry, State University of New York at Albany, Albany, New York, USA.
Catalysis Reviews, Science and Engineering
|January 6, 2015
Summary
This review explores element-cyano bond cleavage reactions, crucial for organic synthesis. Transition metal catalysis enables efficient functionalization, creating new cyano groups and molecular skeletons in one pot.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- The cyano group is a vital intermediate in organic synthesis, readily converting to amines, amides, and acids.
- Element-cyano bond cleavage offers a powerful strategy for one-pot synthesis of functionalized molecules.
- Numerous element-cyano bonds (H-CN, Si-CN, C-CN, B-CN, Sn-CN, Ge-CN, S-CN, Halo-CN, N-CN, O-CN) are amenable to activation.
Purpose of the Study:
- To review recent advancements in transition metal-catalyzed reactions involving element-cyano bond activation.
- To highlight the versatility of cyano group transformations through bond cleavage strategies.
- To provide a comprehensive summary of progress in this significant research area.
Main Methods:
- Focus on transition metal catalysis for element-cyano bond activation.
- Analysis of reactions involving cleavage of diverse element-cyano bonds.
- Literature review of synthetic methodologies and applications.
Main Results:
- Demonstration of efficient cyano group introduction and skeleton functionalization via element-cyano bond cleavage.
- Highlighting the broad scope of applicable element-cyano bonds.
- Showcasing the utility of transition metal catalysts in these transformations.
Conclusions:
- Element-cyano bond activation is a key strategy for accessing diverse functionalized molecules.
- Transition metal catalysis plays a pivotal role in enabling these transformations.
- This methodology offers significant potential for streamlined organic synthesis.
Keywords:
Bond activationCarbon-carbon formationDehydrogenative coupling reactionsElements-cyanoTransition metalsMore Related Videos
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