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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Updated: Apr 19, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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[Stem cells and cancer].

Francisco Arvelo1, Carlos Cotte, Felipe Sojo

  • 1Fundación IDEA, Carretera Nacional Hoyo de la Puerta, Edo, Miranda Venezuela. franarvelo@yahoo.com

Investigacion Clinica
|January 7, 2015
PubMed
Summary
This summary is machine-generated.

Cancer stem cells drive tumor recurrence and drug resistance. Understanding their biology offers new therapeutic strategies to combat cancer and prevent its return.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Context:

  • Despite advances in surgery, radiotherapy, and chemotherapy, cancer remains a significant global health challenge.
  • Cancer stem cells (CSCs) are a critical subpopulation within tumors, influencing disease progression.
  • Understanding CSCs is vital for addressing tumor recurrence, metastasis, and therapeutic resistance.

Purpose:

  • To summarize the key characteristics and properties of cancer stem cells.
  • To review current research on cancer stem cells.
  • To outline strategies for preventing and controlling tumor recurrence driven by CSCs.

Summary:

  • Cancer stem cells (CSCs) are tumor-forming cells responsible for recurrence, metastasis, and drug resistance.
  • Their unique biology, including dormancy-to-malignancy transitions, presents new therapeutic targets.
  • Research focuses on CSC properties and environmental interactions to develop novel anti-cancer treatments.

Impact:

  • Provides a comprehensive overview of cancer stem cell research for scientists and clinicians.
  • Highlights the potential of targeting CSCs for more effective cancer therapies.
  • Offers insights into preventing and managing tumor recurrence, improving patient outcomes.