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Pemphigus in the Arab world.

Marwah A Saleh1

  • 1Department of Dermatology, Cairo University, Cairo, Egypt.

The Journal of Dermatology
|January 7, 2015
PubMed
Summary
This summary is machine-generated.

Pemphigus vulgaris and pemphigus foliaceus prevalence varies across Arab countries due to environmental factors. Understanding these differences is key to unraveling pemphigus disease pathogenesis.

Keywords:
Arabautoimmune bullous diseaseepidemiologypemphigus foliaceuspemphigus vulgaris

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Area of Science:

  • Dermatology
  • Epidemiology
  • Environmental Health

Background:

  • Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are major autoimmune blistering diseases.
  • These subtypes exhibit varying prevalence across diverse Arab nations.
  • Geographical and environmental variations influence subtype distribution.

Purpose of the Study:

  • To investigate the geographical and environmental factors influencing pemphigus subtype prevalence in the Arab world.
  • To explore potential environmental triggers for pemphigus pathogenesis.
  • To understand the diversity in pemphigus treatment regimens across the region.

Main Methods:

  • Comparative analysis of pemphigus subtype distribution in various Arab countries.
  • Review of environmental factors, including traditional cosmetics and farming, as potential risk factors.
  • Examination of autoantibody profiles in relation to geographical and environmental exposures.

Main Results:

  • Pemphigus vulgaris is dominant in Egypt, Sudan, Morocco, Syria, Kuwait, Saudi Arabia, and Yemen.
  • Pemphigus foliaceus is more prevalent in Libya and endemic in Tunisia, with urban variations noted in Morocco.
  • Environmental factors like traditional cosmetics (Tunisia) and farming (Egypt, Tunisia, Sudan) are implicated in disease pathogenesis.

Conclusions:

  • Geographical and environmental factors significantly contribute to the varying prevalence of pemphigus subtypes in the Arab world.
  • Identifying specific environmental triggers is crucial for understanding pemphigus pathogenesis.
  • Standardizing pemphigus treatment protocols across Arab countries is needed.