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Related Experiment Video

Updated: Apr 19, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Endoglin (CD105) expression in sinonasal polyposis.

Giancarlo Ottaviano1, Rocco Cappellesso2, Ioannis Mylonakis3

  • 1Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy. giancarlo.ottaviano@unipd.it.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|January 7, 2015
PubMed
Summary

Recurrent chronic rhinosinusitis with nasal polyps (CRS with NP) is common. While endoglin (CD105) expression showed some links to polyp size and eosinophilic histology, only asthma, hypereosinophilia, and polyp score predicted recurrence.

Keywords:
CD105Nasal polyposisNasal polyps relapseSurgery

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Area of Science:

  • Otorhinolaryngology
  • Immunology
  • Oncology

Background:

  • Chronic rhinosinusitis with nasal polyps (CRS with NP) frequently recurs post-surgery.
  • Angiogenesis is implicated in CRS with NP pathogenesis.
  • Endoglin (CD105), a transforming growth factor-beta receptor component, plays a role in angiogenesis.

Purpose of the Study:

  • To investigate the association between CD105 expression and clinicopathological features in CRS with NP.
  • To determine the prognostic significance of CD105 and other factors for NP recurrence.

Main Methods:

  • Immunohistochemical assessment of CD105 expression in 70 surgically treated CRS with NP patients.
  • Univariate and multivariate analyses correlating CD105, clinicopathological features, and recurrence rates.

Main Results:

  • CD105 expression intensity correlated with larger NP size and eosinophilic histology.
  • Asthma, hypereosinophilia, and preoperative polyposis score were independent predictors of NP recurrence in multivariate analysis.
  • CD105 expression showed a trend towards association with NP dimensions but did not independently predict recurrence.

Conclusions:

  • Asthma, hypereosinophilia, and high preoperative polyposis score are key indicators for predicting CRS with NP recurrence.
  • Enhanced postoperative care, including closer monitoring and targeted therapies, is recommended for high-risk patients.
  • Further research is needed to clarify the role of angiogenesis and proliferation in recurrent NP.