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Updated: Apr 19, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro
Xuemei Lin1, Yu Du2, Yuying Tang1
1Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
Background:
5-HT3 receptor antagonists are effective antiemetics for perioperative use. However, their effects on myometrial contractility remain unknown. We examined whether three different 5-HT3 receptor antagonists could affect the contraction of human myometrium.
Methods:
Samples of human myometrium were taken from parturients undergoing elective cesarean delivery. Effects of ondansetron, granisetron and tropisetron (over a range of 1-10(4)ng/mL) on spontaneous contraction (ratios of amplitude, interval, and duration of the contraction) were examined and compared to saline controls (n=6 for each agent).
Results:
None of the three 5-HT3 receptor antagonists significantly affected myometrial contraction.
Conclusion:
5-HT3 receptor antagonists do not affect the contraction of myometrial strips isolated from term pregnant women.
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