Related Experiment Video
Updated: Apr 19, 2026
Animal Models of Depression - Chronic Despair Model CDM
Published on: September 23, 2021
Physiological Parameters in the Blood of a Murine Stress-Induced Depression Model before and after Repeated Passive
Tae Kyung Kim1, Jin Young Park1, Pyung Lim Han2,3,4
1Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea.
Background:
Animal models are necessary to study the mechanism underlying the effects of exercise on depression but an effective procedure for exercise treatment and exercise effects on physiological parameters in a specific depression model need to be characterized.
Methods:
Physiological parameters including lactate, partial pressue of O₂ (pO₂) and CO₂ (pCO₂) saturated O₂ (sO₂), pH, HCO₃, total CO₂ (TCO₂), and base excess extracellular fluid (BEecf) levels in the blood were measured after treatment with passive exercise in normal mice and a stress-induced depression model.
Results:
Normal mice or mice that were subjected to daily 2-hour restraint for 14 days (2 hours × 14 days of restraint) were placed on a running wheel that was rotating at a speed of 9 m/min for 1 hour per day for 1 to 21 days. After repeated exercise in mice that were previously subjected to 2 hours × 14 days restraint, plasma lactate levels decreased, the levels of pO₂, sO₂, and pH tended to increase, and the levels of pCO₂ decreased in the absence of significant changes in HCO₃, TCO₂, and BEecf. However, none of these changes were additive to the stress effects or were much more severe than those induced after repeated passive exercise in normal mice.
Conclusion:
These results suggest that passive exercise for 1 hour daily for 14 to 21 consecutive days on a running wheel rotating at a speed of 9 m/min may be used as an exercise protocol without inducing severe additive effects on physiological burdens.
