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Related Experiment Videos

Pick bodies in the locus ceruleus.

L S Forno1, L F Eng, D J Selkoe

  • 1Department of Pathology, Veterans Administration Medical Center, Palo Alto, CA 94304.

Acta Neuropathologica
|January 1, 1989
PubMed
Summary

Pick bodies in the locus ceruleus retain distinct microscopic and immunochemical features, differing from Lewy bodies. These differences highlight separate disease pathways for Pick's and Parkinson's diseases.

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Area of Science:

  • Neuropathology
  • Neuroscience

Background:

  • Pick's disease and Parkinson's disease are distinct neurodegenerative disorders.
  • Inclusions called Pick bodies and Lewy bodies are found in the brain, with Lewy bodies more common in the locus ceruleus.

Observation:

  • Pick bodies were studied in the locus ceruleus using light and electron microscopy.
  • Comparison was made between Pick bodies and Lewy bodies in this specific brain region.

Findings:

  • Pick bodies in the locus ceruleus showed unique characteristics, including multiple inclusions per cell, basophilic staining, and intense argyrophilia.
  • Immunocytochemistry revealed strong reactions for tau and paired helical filaments in Pick bodies, unlike Lewy bodies.
  • Electron microscopy showed Pick bodies composed of random filaments, distinct from the core-and-halo structure of Lewy bodies.

Implications:

  • The distinct features of Pick bodies in the locus ceruleus suggest different origins and disease mechanisms compared to Lewy bodies.
  • These findings reinforce the pathological and clinical distinctions between Pick's disease and Parkinson's disease.

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