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Aggressive insulinoma with bone metastases
C S Hesdorffer1, M Stoopler, J Javitch
1Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
American Journal of Clinical Oncology
|December 1, 1989
Summary
Malignant insulinoma can aggressively spread to bone, a rare occurrence. Current chemotherapy, including etoposide and cis-platinum, showed limited efficacy in this advanced case.
Area of Science:
- Oncology
- Endocrinology
- Medical Case Reports
Background:
- Insulinomas are rare neuroendocrine tumors arising from pancreatic beta cells.
- Bone metastases are an uncommon but severe complication of malignant insulinomas.
Observation:
- This report details the first documented case of bone metastases in a patient with insulinoma.
- The patient's condition rapidly deteriorated following the development of bone metastases.
Findings:
- Chemotherapy with etoposide (VP-16) and cis-platinum was ineffective in managing the advanced disease.
- The malignant insulinoma exhibited an unusually aggressive clinical course.
Implications:
- This case highlights the aggressive potential of malignant insulinoma and the limitations of current treatments.
- Further research into novel therapeutic strategies for advanced malignant insulinoma is warranted.