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Hematological parameters in adolescents with hyperuricemia.

Marian J Stelmach1, Lukasz Szczerbinski, Natalia Wasilewska

  • 1Department of Pediatric Nephrology, Medical University of Bialystok, Poland. Correspondence to: Dr Marian Stelmach, Department of Health and Social Sciences, Pope John Paul II State School of Higher Education, 95/97 Sidorska Street, 21-500 Biala Podlaska, Poland. marian.stelmach@me.com.

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This study found that elevated serum uric acid in adolescents is linked to higher BMI and certain blood cell counts. These hematological markers may indicate cardiometabolic risk in this population.

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Area of Science:

  • Pediatric Nephrology
  • Adolescent Health
  • Metabolic Syndrome

Background:

  • Hyperuricemia is increasingly recognized in adolescents.
  • Understanding its associations with other health indicators is crucial for early intervention.
  • Hematological indices may offer insights into associated risks.

Purpose of the Study:

  • To investigate the relationship between serum uric acid levels and various hematological parameters in adolescents.
  • To determine if these hematological markers are associated with cardiometabolic risk factors in this age group.

Main Methods:

  • A 10-year retrospective cohort study involving 607 adolescents diagnosed with hyperuricemia.
  • Data analysis focused on correlations between serum uric acid and hematological indices, including blood cell counts and hemoglobin.
  • Comparison of hematological parameters in adolescents with and without metabolic syndrome.

Main Results:

  • A significant positive correlation was observed between serum uric acid levels and Body Mass Index (BMI) Z-scores.
  • Serum uric acid also showed a positive correlation with white blood cell count, red blood cell count, hemoglobin, and hematocrit.
  • Adolescents with metabolic syndrome exhibited higher levels of hemoglobin, hematocrit, and red blood cells compared to those without.

Conclusions:

  • Hematological parameters, such as red blood cell count and hemoglobin, are significantly associated with hyperuricemia in adolescents.
  • These hematological findings may serve as potential biomarkers for identifying cardiometabolic risk in adolescents with elevated uric acid levels.
  • Further research is warranted to explore the clinical utility of these markers in managing adolescent hyperuricemia.