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Incomplete Lemierre syndrome

Joseph Shiber1, Emily Fontane, Ronald Rabinowitz

  • 1*From the UF College of Medicine, Jacksonville, FL; and †University of Maryland/R Adams Cowley Shock Trauma Center, Baltimore, MD.

Pediatric Emergency Care
|January 7, 2015
PubMed

Insights

Invasive Fusobacterium infections can cause severe complications, even without internal jugular thrombosis. This condition, termed incomplete Lemierre syndrome, shares the same risks and treatments as classic Lemierre syndrome.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Internal Medicine

Background:

  • Fusobacterium infections can lead to severe septic complications.
  • Lemierre syndrome, a rare thrombotic complication of oropharyngeal infection, typically involves internal jugular vein thrombosis.
  • Septic embolization can cause distant metastatic infections.

Observation:

  • A case of invasive Fusobacterium infection presented with significant distant septic complications but lacked internal jugular thrombosis.
  • The patient's presentation met all other criteria for Lemierre syndrome.
  • This highlights a variant presentation of the syndrome.

Findings:

  • Invasive Fusobacterium infection can manifest with severe septic sequelae without internal jugular vein thrombosis.
  • The underlying mechanism of disease, morbidity, prognosis, and treatment remain consistent with classic Lemierre syndrome.
  • The term 'incomplete Lemierre syndrome' is proposed for such cases.

Implications:

  • Recognizing incomplete Lemierre syndrome is crucial for timely diagnosis and management.
  • This broader definition may improve patient outcomes by ensuring appropriate treatment initiation.
  • Further research into Fusobacterium pathogenesis and associated syndromes is warranted.

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