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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.

C P Johnson1, R L Follmer2, I Oguz3

  • 1Department of Radiology, University of Iowa, Iowa City, IA, USA.

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Bipolar disorder shows abnormal brain metabolism, particularly in white matter and cerebellum, detectable with T1ρ mapping. Lithium treatment normalized cerebellar abnormalities in patients.

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Area of Science:

  • Neuroimaging
  • Psychiatric Research
  • Metabolic Studies

Background:

  • Abnormal brain metabolism is implicated in bipolar disorder, but previous studies lacked whole-brain analysis.
  • Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) offers high spatial resolution for detecting metabolic and microstructural changes.

Purpose of the Study:

  • To investigate whole-brain metabolic and microstructural alterations in bipolar I disorder using T1ρ mapping.
  • To assess the utility of T1ρ mapping as a novel neuroimaging technique in psychiatric research.

Main Methods:

  • Applied quantitative T1ρ mapping to 15 euthymic bipolar I disorder patients and 25 healthy controls.
  • Compared T1ρ values between groups using voxel-wise and regional analyses.
  • Assessed cerebellar T1ρ changes in patients undergoing lithium treatment.

Main Results:

  • Elevated T1ρ values were observed in the cerebral white matter and cerebellum of bipolar patients.
  • These abnormalities were not associated with changes in regional volumes.
  • Cerebellar T1ρ abnormalities were normalized in patients receiving lithium treatment.

Conclusions:

  • T1ρ mapping reveals widespread metabolic or microstructural abnormalities in the brain of bipolar disorder patients.
  • The cerebral white matter and cerebellum are key regions implicated in bipolar disorder.
  • T1ρ mapping shows promise as a valuable tool for psychiatric research and understanding treatment effects.