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Cognitive impairment, genomic instability and trace elements.

A Meramat1, N F Rajab, S Shahar

  • 1Dr Razinah Sharif, Email address: razinah.fsk.ukm.my, Telephone: +603-9289 7459, Fax number: +60326947621.

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Micronutrient deficiencies and aging can impair cognitive function by affecting genomic stability and telomere integrity. Maintaining micronutrient balance is crucial for healthy aging and preventing cognitive decline.

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Area of Science:

  • Nutritional Neuroscience
  • Gerontology
  • Genomics

Background:

  • Cognitive impairments are frequently associated with aging and deficiencies in essential micronutrients.
  • Micronutrients like zinc, copper, iron, and selenium are vital for antioxidant functions and gene regulation (nutrigenomics).
  • Genomic instability is a significant factor contributing to age-related cognitive decline.

Purpose of the Study:

  • To review the role of micronutrients in cognitive impairment.
  • To explore the relationship between micronutrients, genomic stability, and aging.
  • To discuss telomere integrity in the context of aging, cognitive function, and micronutrient status.

Main Methods:

  • Literature review and synthesis of existing research.
  • Discussion of nutrigenomic approaches related to micronutrients and aging.
  • Analysis of the interplay between micronutrients, genomic stability, and telomere integrity.

Main Results:

  • Micronutrient deficiencies and excesses can impact genomic stability, contributing to cognitive decline.
  • Aging processes can be influenced by micronutrient status, affecting biological functions.
  • Telomere integrity is linked to both aging and cognitive impairment, with micronutrients playing a role.

Conclusions:

  • Maintaining micronutrient homeostasis is essential for supporting cognitive function during aging.
  • Understanding the link between micronutrients, genomic stability, and telomere integrity is key for healthy aging.
  • Dietary interventions focusing on essential micronutrients may help mitigate age-related cognitive decline.