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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Trends, fads and ART!

Brian Dale1, Yves Menezo, Gianfranco Coppola

  • 1Centre for Assisted Fertilization, Via Tasso, 480, 80123, Naples, Italy, Brian.Dale@virgilio.it.

Journal of Assisted Reproduction and Genetics
|January 7, 2015
PubMed
Summary

Morphological selection methods like IMSI and TLIM lack predictive value for ART success. Embryo development relies on complex physiological events, not just morphology, limiting current lab interventions.

Area of Science:

  • Reproductive biology
  • Embryology
  • Assisted Reproductive Technology (ART)

Background:

  • Current interest in morphological selection techniques for gametes and embryos in ART.
  • Techniques like IMSI, TLIM, and PGS show limited clinical usefulness due to lack of statistically predictive value.

Purpose of the Study:

  • To evaluate the clinical utility of morphological selection techniques in ART.
  • To highlight the limitations of morphological markers in predicting early embryo success.

Main Methods:

  • Review of existing literature on morphological selection techniques (IMSI, TLIM, PGS).
  • Analysis of the physiological and biochemical requirements for early embryo development.

Main Results:

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  • Morphological markers alone do not predict early embryo success.
  • Physiological and biochemical events, independent of maternal or zygotic genomes, are crucial for development.
  • Previous attempts to identify metabolic markers have failed.

    • Conclusions:

    • Morphological selection techniques have limited clinical application in ART.
    • Embryo quality is determined by complex intrinsic factors not currently improvable ex vivo.
    • Embryologists should focus on minimizing iatrogenic damage during in vitro manipulation.