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Related Concept Videos

Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Pharmacological management
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Peripheral Artery Disease IV: Nursing Management01:26

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
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Updated: Apr 19, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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Repositioning for treating pressure ulcers.

Zena E H Moore1, Seamus Cowman

  • 1School of Nursing & Midwifery, Royal College of Surgeons in Ireland, Dublin, Ireland.

The Cochrane Database of Systematic Reviews
|January 7, 2015
PubMed
Summary
This summary is machine-generated.

Repositioning patients is crucial for pressure ulcer healing, but no studies prove its effectiveness. More research is needed to evaluate repositioning

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Area of Science:

  • Wound healing research
  • Clinical practice guidelines
  • Patient care management

Background:

  • Pressure ulcers result from reduced blood flow and waste removal.
  • Impaired circulation and waste drainage hinder wound healing.
  • Patient repositioning is internationally recognized for pressure ulcer management.

Purpose of the Study:

  • To evaluate the impact of patient repositioning on pressure ulcer healing rates.
  • To clarify the role of repositioning in managing existing pressure ulcers.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) and controlled clinical trials (CCTs).
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to August 2014.
  • Studies compared repositioning interventions against no repositioning, different techniques, or frequencies.

Main Results:

  • No studies met the inclusion criteria for this review.
  • No randomized trials were identified to assess repositioning's effect on pressure ulcer healing.

Conclusions:

  • The effectiveness of repositioning for pressure ulcer healing remains unproven due to a lack of evidence.
  • Further research, specifically RCTs, is required to determine the impact of repositioning on wound healing.
  • Clinical practice should be guided by evidence, highlighting the need for studies in this area.