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Systemic sclerosis in 2014: Advances in cohort enrichment shape future of trial design

Yannick Allanore1, Oliver Distler2

  • 1Department of Rheumatology A, Medicine Faculty, Paris Descartes University, 27 Rue du Faubourg Saint Jacques, Cochin Hospital, 75014 Paris, France.

Nature Reviews. Rheumatology
|January 7, 2015
PubMed

Insights

Systemic sclerosis (SSc) treatment is advancing with new clinical trials. Future research should refine patient selection for targeted therapies, improving SSc management.

Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Trials

Background:

  • Systemic sclerosis (SSc) pathogenesis understanding has improved.
  • Several randomized controlled trials (RCTs) in SSc are emerging.
  • Previous trial designs from 2014 require further development.

Purpose of the Study:

  • To highlight the evolving landscape of systemic sclerosis treatment.
  • To emphasize the need for enhanced patient stratification in SSc clinical trials.
  • To advocate for precision medicine approaches in SSc therapy.

Main Methods:

  • Review of recent advancements in SSc clinical trial design.
  • Analysis of the impact of improved SSc pathogenesis knowledge.
  • Discussion on strategies for optimizing patient selection in SSc studies.

Main Results:

  • The field of SSc treatment is undergoing significant transformation.
  • Current trial designs are based on a better grasp of SSc.
  • There is a clear need for improved patient subgroup identification.

Conclusions:

  • Systemic sclerosis research is entering a new era of therapeutic development.
  • Building upon 2014 trial design advancements is crucial.
  • Enhanced patient selection will enable targeted SSc therapies for specific subgroups.

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