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Lisinopril dose-response relationship in essential hypertension
H J Gomez1, V J Cirillo, J A Sromovsky
1Department of Cardiovascular Clinical Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065-0900.
British Journal of Clinical Pharmacology
|October 1, 1989
Summary
Lisinopril effectively lowers blood pressure in patients with essential hypertension. Higher doses of lisinopril demonstrated significantly greater diastolic blood pressure reductions compared to placebo.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension is a common condition requiring effective treatment.
- Blood pressure management is crucial for cardiovascular health.
Purpose of the Study:
- To evaluate the efficacy and tolerability of lisinopril in patients with mild to moderate essential hypertension.
- To determine the dose-response relationship of lisinopril on blood pressure reduction.
Main Methods:
- A multicentre, double-blind, parallel study involving 216 patients.
- Patients received placebo or lisinopril (1.25, 5, 20, or 80 mg) daily for 6 weeks after a 4-week placebo washout.
- Blood pressure was measured at multiple time points, 24 hours postdose.
Main Results:
- A linear dose-response relationship was observed for both supine and erect blood pressure.
- Significant reductions in diastolic blood pressure were noted with lisinopril 20 and 80 mg compared to placebo and lower doses.
- Lisinopril was well tolerated across all tested doses.
Conclusions:
- Lisinopril demonstrates dose-dependent efficacy in reducing blood pressure in essential hypertension.
- Lisinopril is a well-tolerated treatment option for managing mild to moderate essential hypertension.