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Updated: Apr 19, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
T helper cell dysregulation with hepatitis B and rebalance with glucocorticoids
Zhong-Hua Lu1, Xiao-Ping Huang1, Wei Sun1
1Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.
Aim:
To investigate T helper 17/regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids.
Methods:
The study included 20 patients in the early stage of severe hepatitis B (SHB) and 11 healthy controls. All patients had elevated T helper 17 (Th17) levels, decreased regulatory T (Treg) cell levels, and significant Th17/Treg ratios.
Results:
After glucocorticoid treatment, 16 patients showed improvement with significant decreases in Th17 levels, increases in Treg, and rebalanced Th17/Treg ratios. The four patients who showed no improvement had increases in both Th17 and Treg levels and an even higher Th17/Treg ratio than before.
Conclusion:
Glucocorticoid treatment can rectify Th17/Treg dysregulation in patients with SHB.
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