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Dynamic changes in sRAGE levels and relationship with cardiac function in STEMI patients

Louise J N Jensen1, Søren Lindberg2, Søren Hoffmann2

  • 1The Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Noerrebrogade 44, DK-8000 Aarhus C, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark.

Clinical Biochemistry
|January 7, 2015
PubMed

Insights

Soluble receptor of advanced glycation end-products (sRAGE) levels rise early in acute myocardial infarction (AMI), even before Troponin I. Elevated sRAGE is linked to long-term cardiac dysfunction after treatment.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Acute Myocardial Infarction

Background:

  • Soluble receptor of advanced glycation end-products (sRAGE) is a potential biomarker in coronary artery disease (CAD).
  • Patients with acute myocardial infarction (AMI) exhibit elevated sRAGE levels compared to healthy individuals.

Purpose of the Study:

  • To investigate dynamic changes in sRAGE levels during AMI.
  • To determine the relationship between sRAGE levels and cardiac dysfunction post-AMI.

Main Methods:

  • Prospective study of 80 ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI).
  • sRAGE concentrations measured pre-pPCI, immediately post-pPCI, and on days 1 and 2 post-pPCI.
  • Left ventricular ejection fraction (LVEF) and infarct size assessed via echocardiography and cardiac MRI.

Main Results:

  • sRAGE levels significantly increased post-pPCI compared to pre-pPCI (median ratio: 1.25), preceding Troponin I elevation.
  • sRAGE levels decreased substantially by day 1 post-pPCI (median ratio: 0.34).
  • Peak sRAGE independently correlated with long-term cardiac dysfunction (LVEF) and infarct size.

Conclusions:

  • sRAGE levels peak early in AMI and post-pPCI, decreasing thereafter.
  • The rise in sRAGE precedes detectable Troponin I changes.
  • sRAGE is an independent predictor of long-term cardiac dysfunction following AMI.
Abstract

Keywords:
Acute myocardial infarctionBiomarkerLeft ventricular ejection fractionPrimary percutaneous coronary interventionSoluble receptor of advanced glycation end-productssRAGE

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