Novel polyacetylenes from Coreopsis tinctoria Nutt

Area of Science:

• Natural Product Chemistry
• Pharmacology

Background:

• Coreopsis tinctoria Nutt. is a plant with potential medicinal properties.
• Polyacetylenes are a class of natural compounds with diverse biological activities.

Purpose of the Study:

• To isolate and characterize novel polyacetylenes from Coreopsis tinctoria.
• To evaluate the anti-proliferative and anti-inflammatory activities of isolated compounds.

Main Methods:

• Phytochemical investigation using 95% EtOH extract.
• Structure elucidation via 2D NMR, HR-MS, and optical rotation.
• In vitro assays for anti-proliferative activity (C26 cells) and nitric oxide inhibition (RAW 264.7 cells).

Main Results:

• Two novel polyacetylenes, (2S)-(3Z,11E)-decadiene-5,7,9-triyne-1,2-diol (1) and (2R)-(3E,11Z)-decadiene-5,7,9-triyne-1,2-diol (2), were isolated.
• Two known polyacetylenes (3 and 4) were also identified.
• Compounds 1, 2, and 4 exhibited weak anti-proliferative and nitric oxide inhibitory effects.

Conclusions:

• The study identified novel polyacetylenes from Coreopsis tinctoria.
• The isolated compounds demonstrated limited anti-proliferative and anti-inflammatory potential in the tested assays.