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Possible mechanism of the stimulatory effect of 4-aminopyridine on toad skin
C S González1, B C Norris, J B Concha
1Department of Physiological Sciences, Faculty of Biological and Natural Sciences, University of Concepcion, Chile.
General Pharmacology
|January 1, 1989
Abstract:
1. This study was undertaken to demonstrate the facilitatory effects of 4-aminopyridine on transmitter release in the toad skin preparation. 2. A dose-dependent increase in the bioelectric parameters was found. 3. This effect was blocked by propranolol and by verapamil but not by dibenamine, and was mimicked by the calcium ionophore A-23187 but not by potassium channel blockers. 4. These results support the hypothesis that 4-aminopyridine increases presynaptic nerve terminal permeability of calcium and thus the release of noradrenaline.