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Updated: Apr 18, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

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Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies

Rajendra Gharbaran1

  • 1Biological Sciences, State University of New York College of Old Westbury, 233 Store Hill Road, Old Westbury, NY 11568, USA.

Critical Reviews in Oncology/Hematology
|January 8, 2015
PubMed

Insights

Syndecan-1 (SDC1) promotes cancer progression by enhancing cell growth, invasion, and angiogenesis. Targeting SDC1 may offer new therapeutic strategies for cancer treatment and overcoming resistance.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Syndecan-1 (SDC1), a cell surface heparan sulfate proteoglycan, is crucial for various biological functions.
  • Altered SDC1 expression is linked to malignant phenotypes including increased proliferation, survival, invasion, metastasis, and angiogenesis.

Purpose of the Study:

  • To review the pro-tumorigenic roles of Syndecan-1 (SDC1) in cancer.
  • To discuss the impact of SDC1 on clinical cancer progression, relapse, and therapeutic resistance.
  • To explore current strategies targeting SDC1 and its signaling pathways.

Main Methods:

  • Literature review of recent studies on SDC1's molecular roles in cancer.
  • Analysis of SDC1's prognostic significance in various cancers.
  • Examination of SDC1's involvement in cancer stem cells (CSCs) and therapeutic resistance.

Main Results:

  • SDC1 significantly contributes to tumor growth, invasion, metastasis, and angiogenesis.
  • SDC1 expression levels correlate with clinical outcomes and prognosis in cancer patients.
  • SDC1 plays a role in stimulating cancer stem cells (CSCs), potentially leading to relapse and treatment resistance.

Conclusions:

  • SDC1 exhibits significant pro-tumorigenic functions across various cancers.
  • SDC1's role in CSCs highlights its importance in disease relapse and therapeutic resistance.
  • Targeting SDC1 presents a promising avenue for novel cancer therapies.
Keywords:
CancerHematologyOncologyStem cellsSyndecan-1/CD138Tumor

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