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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Published on: August 14, 2019

Diffusional kurtosis and diffusion tensor imaging reveal different time-sensitive stroke-induced microstructural

Rachel A Weber¹, Edward S Hui¹, Jens H Jensen¹

¹From the Department of Neurosciences (R.A.W., M.F.F., J.A.H., D.L.A.), Center for Biomedical Imaging (J.H.J., X.N., M.F.F., J.A.H., D.L.A.), Department of Radiology and Radiological Science (J.H.J., X.N., M.F.F., J.A.H.), and Health Sciences and Research, College of Health Professions (D.L.A.), Medical University of South Carolina, Charleston; and Department of Diagnostic Radiology, University of Hong Kong, Pokfulam, Hong Kong (E.S.H.).

|January 8, 2015

Summary

This summary is machine-generated.

Diffusion MRI detects gray matter changes after stroke. Mean kurtosis and mean diffusivity (MD) offer complementary insights into acute and chronic microstructural alterations, with glia infiltration influencing MD changes.

Keywords:

diffusion tensor imaging glial fibrillary acidic protein ischemia motor cortex stroke

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neuroimaging
Stroke Research
Diffusion MRI

Background:

Diffusion MRI is a clinically feasible technique for assessing white matter changes post-stroke.
Its sensitivity in detecting gray matter microstructural alterations after stroke requires further investigation.

Purpose of the Study:

To evaluate the sensitivity of diffusion MRI in detecting gray matter microstructural changes in the perilesional cortex following sensorimotor cortex stroke in rats.
To compare diffusion MRI metrics (mean diffusivity and mean kurtosis) with glial and axonal densities.

Main Methods:

Diffusion MRI metrics (mean diffusivity and mean kurtosis) were measured in the perilesional motor cortex at various time points post-stroke.
These metrics were compared to the contralesional cortex and correlated with glial, dendritic, and axonal densities.

Main Results:

Perilesional mean kurtosis increased at 72 hours and 25 days post-stroke.
Mean diffusivity showed no significant difference at 24 hours but correlated with increased glial processes at 72 hours.
Glia density changes correlated with mean diffusivity at 72 hours but not at 25 days.

Conclusions:

Mean kurtosis and mean diffusivity provide distinct, complementary information on acute and chronic perilesional cortex changes.
Glia infiltration is linked to MD pseudonormalization at 72 hours, an association absent at 25 days.
Time-specific microstructural changes underlie these diffusion measures, highlighting their complex relationship.