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Updated: Apr 18, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
Photosensitive GFP mutants containing an azobenzene unnatural amino acid
Marshall S Padilla1, Douglas D Young1
1Department of Chemistry, College of William & Mary, Williamsburg, VA 23187, USA.
Abstract:
The incorporation of unnatural amino acids represents a unique mechanism for the modulation of protein function. This approach has been utilized to generate photoswitchable GFP mutants, capable of demonstrating modulated fluorescence upon exposure to UV irradiation. Overall these photosensitive GFP mutants can be employed in various biosensing and diagnostic techniques to better understand protein function and processing.
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