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Updated: Apr 18, 2026
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Contact heat evoked potentials and habituation measured interictally in migraineurs
Lena Clara Beese, Denise Putzer, Nani Osada
1Department of General Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany. martin.marziniak@kbo.de.
Background:
A lack of habituation of different evoked potential modalities in migraine patients in-between attacks has been suggested.
Methods:
This study investigates cortical response after painful stimuli evaluated by contact heat evoked potentials (CHEPs) and quantitative sensory testing (QST) during the migraine-free interval. We enrolled 22 migraine patients and 22 healthy subjects.
Results:
Cortical potentials after contact heat stimulation of the cheeks and the volar forearm at a temperature of 51°C showed significantly reduced A-δ-amplitudes in patients and healthy controls. When the subjects' attention was drawn to an arithmetic task, a partial lack of habituation of amplitude could be seen in migraine patients. QST did not show any difference between migraineurs and controls.
Conclusion:
Our findings can be primarily deemed to demonstrate that patients and healthy controls show significantly lower amplitudes while performing the calculation task. Without performing the calculation task we could not show the expected lack of habituation in migraineurs. Yet, while performing the calculation task our results partly suggest that hypothesis.
