Related Experiment Video

Updated: Apr 18, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.2K

Dietary nucleotide and nucleoside exposure in infancy and atopic dermatitis, recurrent wheeze, and allergic

Marijke J C Timmermans1, Pieter C Dagnelie, Esther H E Theunisz

  • 1Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.

Journal of Pediatric Gastroenterology and Nutrition
|January 8, 2015
PubMed

Insights

Early life exposure to nucleotides and nucleosides did not significantly reduce the risk of allergies like wheeze or atopic dermatitis in children up to two years old. This study found no clear association between these exposures and the development of atopic outcomes.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Science
  • Clinical Research

Background:

  • Nucleotides and nucleosides are essential components for cellular function and immune system development.
  • Dietary exposure to nucleotides and nucleosides occurs through breast milk and infant formulas.
  • Previous research suggests potential immunomodulatory roles for nucleotides and nucleosides.

Purpose of the Study:

  • To investigate the association between early life exposure to nucleotides and nucleosides and the risk of developing atopic outcomes.
  • To evaluate the impact of nucleotide and nucleoside exposure via breast milk and formula on allergic sensitization, recurrent wheeze, and atopic dermatitis in infants.

Main Methods:

  • A cohort of 429 children was studied.
  • Nucleotide and nucleoside concentrations were measured in breast milk (using high-performance liquid chromatography) and infant formulas (obtained from manufacturers).
  • Atopic outcomes, including recurrent wheeze, atopic dermatitis, and allergic sensitization, were assessed through questionnaires and home visits up to age 2.

Main Results:

  • In predominantly formula-fed children, adjusted odds ratios for atopic outcomes in the highest tertile of exposure ranged from 1.11 to 1.99 compared to the lowest tertile, but were not statistically significant.
  • In predominantly breast-fed children, adjusted odds ratios ranged from 0.40 to 0.53, also not reaching statistical significance.
  • No significant evidence of association was found between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.

Conclusions:

  • The study found no evidence to support the hypothesis that early life exposure to nucleotides and nucleosides protects against common atopic diseases in children.
  • Further research may be needed to explore other dietary factors or different exposure windows in relation to atopic disease development.

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.4K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.6K

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
3
Allergic Reactions02:06

Allergic Reactions

Overview
34.4K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
181
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
46
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.7K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
6.0K