Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of naloxone on hormonal changes during exercise.

N Mesaki1, J Sasaki, M Motobu

  • 1Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki.

Nihon Sanka Fujinka Gakkai Zasshi
|December 1, 1989
PubMed
Summary

Naloxone, an opioid antagonist, suppressed exercise-induced increases in prolactin and beta-endorphin in female athletes. This suggests a role for endogenous opioids in regulating prolactin release during physical exertion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.

Atherosclerosis·1998
Same author

Supernumerary ring chromosomes and nuclear blebs in some low-grade malignant soft tissue tumours: atypical lipomatous tumours and dermatofibrosarcoma protuberans.

Virchows Archiv : an international journal of pathology·1998
Same author

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.

Genes to cells : devoted to molecular & cellular mechanisms·1998
Same author

Reirradiation therapy for brain metastases from small cell lung cancer.

Radiation medicine·1998
Same author

Remission induction by granulocyte colony-stimulating factor in hypoplastic acute myelogenous leukemia complicated by infection. A case report and review of the literature.

Acta haematologica·1998
Same author

[The efficacy of low-dose propofol for intrathecal morphine-induced pruritus].

Masui. The Japanese journal of anesthesiology·1998

Area of Science:

  • Exercise Physiology
  • Endocrinology
  • Neuroscience

Background:

  • Exercise-induced menstrual dysfunction is linked to prolactin release.
  • Understanding the mechanisms of prolactin regulation during exercise is crucial.

Purpose of the Study:

  • To investigate the role of endogenous opioids in exercise-induced prolactin release.
  • To examine the effects of naloxone on hormonal changes during incremental exercise in female athletes.

Main Methods:

  • Ten female athletes underwent incremental cycle ergometer exercise.
  • Naloxone was administered intravenously and via continuous infusion during exercise.
  • Serum and plasma levels of prolactin, dopamine, beta-endorphin, VIP, and ACTH were measured at rest, during exercise, and post-exercise.

Related Experiment Videos

Main Results:

  • Exercise significantly increased prolactin, beta-endorphin, and VIP levels.
  • Naloxone administration suppressed the exercise-induced increases in prolactin and beta-endorphin.
  • Dopamine levels remained unchanged, while ACTH showed a non-significant trend towards decrease with naloxone.

Conclusions:

  • Endogenous opioids, modulated by naloxone, play a significant role in exercise-induced prolactin release.
  • These findings contribute to understanding the neuroendocrine regulation of prolactin during physical activity.