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Updated: Apr 18, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Technologies to probe functions and mechanisms of long noncoding RNAs
Ci Chu1, Robert C Spitale2, Howard Y Chang3
1Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.
Abstract:
Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional characterization has been slowed by a limited set of research tools. Here we review emerging RNA-centric methods to interrogate the intrinsic structure of lncRNAs as well as their genomic localization and biochemical partners. Understanding these technologies, including their advantages and caveats, and developing them in the future will be essential to progress from description to comprehension of the myriad roles of lncRNAs.
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