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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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PLGA: a unique polymer for drug delivery.

Deepak N Kapoor1, Amit Bhatia, Ripandeep Kaur

  • 1School of Pharmaceutical Sciences (LSPS), Faculty of Applied Medical Sciences (LFAMS), Lovely Professional University (LPU), Phagwara, Punjab, India.

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Polylactic-co-glycolic acid (PLGA) is a smart biodegradable polymer widely used for controlled drug delivery. This review covers PLGA

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Biodegradable polymers are crucial for advanced drug delivery systems.
  • Polylactic-co-glycolic acid (PLGA) is a prominent synthetic polymer with desirable characteristics for biomedical applications.
  • PLGA exhibits stimuli-sensitive behavior, earning it the designation of a 'Smart Polymer'.

Purpose of the Study:

  • To provide a comprehensive overview of polylactic-co-glycolic acid (PLGA) in the context of drug delivery.
  • To discuss the chemistry, properties, and applications of PLGA-based drug delivery systems.
  • To enumerate and analyze various drug-polymer combinations utilized in drug carriers.

Main Methods:

  • Literature review of scientific publications on PLGA and drug delivery.
  • Analysis of chemical structure, physicochemical properties, and biodegradation pathways of PLGA.
  • Compilation and discussion of reported PLGA-based drug delivery systems and their applications.

Main Results:

  • PLGA possesses favorable properties for controlled and targeted drug delivery.
  • PLGA's stimuli-sensitive nature enables sophisticated therapeutic strategies.
  • Numerous PLGA-based systems have been developed for treating diverse diseases.

Conclusions:

  • PLGA is a versatile and effective polymer for developing advanced drug delivery systems.
  • Understanding PLGA's characteristics is key to optimizing its use in pharmaceutical formulations.
  • PLGA continues to be a significant material in the field of targeted and controlled therapeutics.