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Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Updated: Apr 18, 2026

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
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Solid-state protein formulations.

Ukrit Angkawinitwong1, Garima Sharma, Peng T Khaw

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

Therapeutic Delivery
|January 8, 2015
PubMed
Summary
This summary is machine-generated.

Solid formulations enhance the stability of therapeutic proteins and peptides, preventing degradation during storage and administration. Key techniques include crystallization, freeze-drying, and particle formation for improved pharmaceutical protein stability.

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Area of Science:

  • Pharmaceutical Science
  • Biotechnology
  • Materials Science

Background:

  • Therapeutic proteins and peptides are prone to chemical degradation in liquid dosage forms.
  • Ensuring protein stability during storage, transport, and administration is critical for effective drug delivery.
  • Solid formulations offer a viable solution to overcome the instability challenges of protein-based therapeutics.

Purpose of the Study:

  • To review current strategies for formulating pharmaceutical proteins in solid dosage forms.
  • To discuss physical instabilities associated with protein formulations.
  • To provide an overview of key solidification techniques and commercial examples.

Main Methods:

  • Overview of physical instabilities in protein formulations.
  • Discussion of solidification techniques: crystallization, freeze-drying, and particle forming technologies.
  • Inclusion of examples of currently marketed solid-state protein products.

Main Results:

  • Physical instabilities can compromise protein integrity in formulations.
  • Crystallization, freeze-drying, and particle forming technologies are effective solidification methods.
  • Commercial products demonstrate the successful application of solid-state protein formulation.

Conclusions:

  • Solid-state formulation is essential for maintaining the stability of therapeutic proteins and peptides.
  • Various techniques exist to achieve stable solid protein formulations.
  • Future advancements in solid-state protein formulation hold promise for improved drug delivery.