Related Experiment Video
Updated: Apr 18, 2026
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
Refinement of animal models of sepsis and septic shock
Elliot Lilley1, Rachel Armstrong, Nicole Clark
1*Research Animals Department, RSPCA, Southwater; †Huntington Life Sciences, Huntington; ‡University College London, London; §Animals in Science Regulation Unit, Home Office, London; ∥Royal Veterinary College, London; ¶The Babraham Institute, Cambridge; **Centre for Biomedical Research, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth; ††The William Harvey Research Institute, Queen Mary University of London, London; and ‡‡Institute of Pharmaceutical Science, Kings College London, London, United Kingdom.
Abstract:
This report aims to facilitate the implementation of the Three Rs (replacement, reduction, and refinement) in the use of animal models or procedures involving sepsis and septic shock, an area where there is the potential of high levels of suffering for animals. The emphasis is on refinement because this has the greatest potential for immediate implementation. Specific welfare issues are identified and discussed, and practical measures are proposed to reduce animal use and suffering as well as reducing experimental variability and increasing translatability. The report is based on discussions and submissions from a nonregulatory expert working group consisting of veterinarians, animal technologists, and scientists with expert knowledge relevant to the field.
More Related Videos
09:17Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
Published on: May 2, 2017
07:03Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
Published on: February 15, 2022