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Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models

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A low-cost programmable pulse generator for physiology and behavior.

Joshua I Sanders¹, Adam Kepecs¹

¹Neuroscience, Cold Spring Harbor Laboratory, Kepecs Lab, Cold Spring Harbor NY, USA.

Frontiers in Neuroengineering

|January 8, 2015

Summary

This summary is machine-generated.

Pulse Pal is an open-source device enabling precise, software-defined voltage pulse trains for neuroscience research. This inexpensive tool offers flexible temporal control, addressing challenges in experimental brain manipulation.

Keywords:

Pulse Pal arduino maple open source optogenetics pulse generator stimulator timing

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Area of Science:

Neuroscience
Biophysics
Instrumentation

Background:

Precise experimental control of brain and sensory stimuli is crucial for understanding brain function.
Existing commercial instruments for generating pulse trains are often expensive and proprietary.

Purpose of the Study:

To introduce Pulse Pal, an open-source device for generating software-defined voltage pulse trains.
To describe the circuitry, firmware, and performance characteristics of Pulse Pal.
To provide resources for users to assemble and utilize Pulse Pal.

Main Methods:

Development of open-source hardware and firmware for Pulse Pal.
Characterization of the temporal precision and reliability of the generated pulse trains.
Provision of online documentation and application programming interfaces (APIs).

Main Results:

Pulse Pal enables the creation of high-temporal-precision, software-defined voltage pulse trains.
The device is characterized for its precision and reliability in stimulus control.
Online resources facilitate assembly, testing, and integration into research workflows.

Conclusions:

Pulse Pal offers an inexpensive, flexible, and open solution for temporal control in neuroscience research.
The device addresses limitations of current commercial instrumentation.
Pulse Pal is expected to facilitate a wide range of neuroscience experiments requiring precise timing.