Evidence-based treatment for Depersonalisation-derealisation Disorder (DPRD)

Area of Science:

• Psychiatry
• Clinical Psychology
• Neuroscience

Background:

• Depersonalisation-derealisation disorder (DPRD) is a poorly understood but distressing condition.
• Growing interest in DPRD pathogenesis and treatment necessitates a review of existing trials.

Purpose of the Study:

• To systematically review randomized controlled trials (RCTs) of pharmacotherapy and psychotherapy for DPRD.
• To assess the efficacy of various interventions for depersonalisation disorder.

Main Methods:

• A comprehensive search of articles from 1980 to 2012 was conducted using Cochrane methods.
• Included RCTs of pharmacotherapy, psychotherapy, and somatic interventions for DPRD.
• PRISMA guidelines were followed, with four studies meeting inclusion criteria.

Main Results:

• Four RCTs involving 180 participants were reviewed, focusing on lamotrigine, fluoxetine, and biofeedback.
• One lamotrigine study showed efficacy (p < 0.001), while another did not (p = 0.61).
• Fluoxetine and biofeedback were not superior to controls; lamotrigine showed inconsistent results.

Conclusions:

• Limited RCT data indicates inconsistent efficacy for lamotrigine in treating DPRD.
• Current evidence does not support the efficacy of other reviewed pharmacotherapy or psychotherapy interventions.
• Further research is crucial to develop effective treatments for depersonalisation disorder.