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Published on: August 11, 2018
Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
Yu-Mi Lee1, Sun-Mi Kim2, Su Jin Park2
1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ; Department of Infectious Diseases, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Abstract:
Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.
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