Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

110
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
110
Bacterial Signaling01:30

Bacterial Signaling

43.7K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
43.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.7K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.7K
The Skin Microbiota01:27

The Skin Microbiota

93
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
93
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

61
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
61

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complete Genome Sequences of Two Bioluminescent Vibrio campbellii Strains Isolated from Biofouling Communities in the Bay of Bengal.

Genome announcements·2018
Same author

Evaluation of Parameters for High Efficiency Transformation of Acinetobacter baumannii.

Scientific reports·2016
Same author

Airworthiness testing of medical maggots.

Military medicine·2015
Same author

Culture-independence for surveillance and epidemiology.

Pathogens (Basel, Switzerland)·2014
Same author

Microbial profiling of combat wound infection through detection microarray and next-generation sequencing.

Journal of clinical microbiology·2014
Same author

Proteomic sample preparation for blast wound characterization.

Proteome science·2014
Same journal

Benchmarking Zero-Shot Generative Pre-Trained Transformer-Based Multimodal Large Language Models for Pressure Injury Staging.

Advances in wound care·2026
Same journal

Does Warmed Saline Irrigation Improve Comfort During Dressing Changes After Digit Replantation? A Randomized Controlled Trial.

Advances in wound care·2026
Same journal

Adult Burn Survivors Face Elevated Long-Term Risk of Major Adverse Cardiovascular Events, Venous Thromboembolism, and Mortality: A Real-World Analysis.

Advances in wound care·2026
Same journal

Management of Infected Wounds: A Wound Healing Foundation Consensus Statement.

Advances in wound care·2026
Same journal

Predicting Harm: A Systematic Review of Pediatric Pressure Injury Models and Their Clinical Shortcomings.

Advances in wound care·2026
Same journal

Development and Validation of a Novel Risk Prediction Model for Incident Diabetic Foot Complications: A Large, Longitudinal, Population-Based Machine Learning Study.

Advances in wound care·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

22.2K

Bacterial Strain Diversity Within Wounds.

Benjamin C Kirkup1

  • 1FE Hébert School of Medicine, Uniformed Services University of the Health Sciences , Bethesda, Maryland.

Advances in Wound Care
|January 8, 2015
PubMed
Summary
This summary is machine-generated.

Wounds harbor a vast diversity of bacterial strains, challenging previous understandings of wound microbiology. New technologies are emerging to study these numerous rare bacteria and their interactions within wound environments.

More Related Videos

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.6K
Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

2.7K

Related Experiment Videos

Last Updated: Apr 18, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

22.2K
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.6K
Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

2.7K

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Wound samples contain numerous rare bacterial taxa and multiple strains within common genera.
  • Previously, wounds were thought to harbor limited bacterial diversity, but recent findings reveal extensive strain variation.

Approach:

  • Utilizing advanced technologies to detect, identify, and characterize bacterial strains in wound samples.
  • Investigating the distribution and potential interactions of diverse bacterial strains within wound microhabitats.

Key Points:

  • Wound environments exhibit significant bacterial diversity, including multiple strains of both gram-negative and gram-positive bacteria.
  • The distribution and interactions of these numerous bacterial strains are not yet well understood.
  • Current technologies for detailed genomic analysis of wound bacteria are still developing.

Conclusions:

  • Recognizing the extensive bacterial diversity in wounds is crucial for understanding wound microbiology.
  • Future research using advanced genomics and microscopy will elucidate the complex interplay of bacterial strains in wound infections.
  • Understanding these interactions is key to developing novel therapeutic strategies for wound care.