Related Experiment Video
Updated: Jan 31, 2026
10:52
Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
Published on: April 12, 2019
13.4K
Emerging understanding of multiscale tumor heterogeneity
Michael J Gerdes1, Anup Sood1, Christopher Sevinsky1
1Diagnostic Imaging and Biomedical Technologies, GE Global Research , Niskayuna, NY , USA.
Frontiers in Oncology
|January 8, 2015
Summary
Cancer is a complex disease with diverse genetic and metabolic changes. Understanding cancer heterogeneity using multiplexed technologies offers new avenues for drug discovery and targeted therapies.
Area of Science:
- Oncology
- Genetics
- Cell Biology
Background:
- Cancer is a multifaceted disease characterized by significant heterogeneity at genetic, cellular, and tissue levels.
- Key features of cancer, such as the 10 acquired capabilities, drive malignant transformation and tumor progression, varying in importance across cancer types.
- Tumorigenesis involves genetic mutations and interactions with the tumor microenvironment, influencing tumor growth and metastasis.
Purpose of the Study:
- To review the features of cancer heterogeneity.
- To discuss the role of multiplexed technologies in understanding these features.
- To highlight the potential of advanced technologies in cancer research and drug discovery.
Main Methods:
- Review of current literature on cancer heterogeneity.
- Examination of genetic alterations (germ-line and somatic mutations).
- Analysis of the tumor microenvironment's components and their roles.
- Discussion of integrated, multi-omic, and multiplexed technologies.
Main Results:
- Cancer heterogeneity is a fundamental characteristic involving genetic alterations and complex cellular interactions.
- The tumor microenvironment significantly influences tumor progression and metastasis.
- Multiplexed technologies are crucial for a comprehensive understanding of tumorigenesis.
- Advancements in understanding cancer mechanisms are paving the way for novel drug targets.
Conclusions:
- A deeper comprehension of cancer heterogeneity is essential for advancing oncology.
- Multiplexed and multi-omic technologies are vital tools for dissecting complex cancer biology.
- This enhanced understanding promises to accelerate the development of new cancer therapies and address drug discovery challenges.
Related Concept Videos
01:28Understanding the Self
286
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
286
01:20Understanding Self-Concept
277
The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
277
01:14Understanding Deception
167
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
167
01:27Understanding Love
189
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
189
01:27Emerging Adulthood
681
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
681
01:23Understanding Consciousness
2.1K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
Sleep, a crucial state, is characterized by reduced...
2.1K