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Updated: Apr 18, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Caffeoylquinic acid derivatives from stems of Akebia trifoliata]
Jing Wang1, Qiao-Lin Xu, Zhong-Yu Zhou
1South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Objective:
To study the chemical constituents from Akebia trifoliata stems.
Methods:
The compounds were isolated and purified by column chromatography, and their structures were determined through spectroscopic techniques and physicochemical properties.
Results:
Six compounds were isolated from the stems of Akebia trifolita and identified as cryptochlorogenic acid methyl ester (1), neochlorogenic acid methyl ester (2), chlorogenic acid methyl ester (3), methyl 3,5-di-O-caffeoyl quinate (4), methyl 3,4-di-O-caffeoyl quinate (5) and methyl 4,5-di-O-caffeoyl quinate (6).
Conclusion:
All compounds are isolated from Akebia genus for the first time. Compounds 1,5 and 6 demonstrate obvious inhibitory activities against α-glucosidase.
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