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Regional distribution of metabotropic glutamate response in the rat brain using Xenopus oocytes
T Horikoshi1, A Asanuma, K Yanagisawa
1Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Neuroscience Letters
|November 6, 1989
Abstract:
The regional distribution of metabotropic L-glutamate responses was investigated in Xenopus oocytes injected with poly(A)+-RNA from a rat brain which was separated into 3 parts: cerebrum, cerebellum and brainstem. Under voltage-clamp, oscillatory current responses were induced more in cerebellum or brainstem poly (A)+-RNA-injected oocytes, and less in cerebrum poly(A)+-RNA-injected oocytes. These results suggest that the metabotropic glutamate receptor is distributed mostly in cerebellum and brainstem.