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Updated: Apr 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Drug eruptions induced by allopurinol associated with HLA-B*5801
Meihua Zeng, Min Zhang, Fang Liu
1Department of Dermatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China 210002, .
Abstract:
Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA-BFNx015801 allele is a very strong marker for allopurinol-induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-BFNx015801 allele and review the literature on the association between HLA-BFNx015801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search.
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