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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
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Gelatin-based particulate systems in ocular drug delivery
Rania M Hathout1, Mohamed K Omran1
1a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.
Pharmaceutical Development and Technology
|January 9, 2015
Summary
Gelatin micro- and nanoparticles show promise for overcoming ocular drug delivery challenges. This review highlights recent successes, encouraging further research into this safe and versatile biomaterial for eye treatments.
Area of Science:
- Ophthalmology
- Materials Science
- Drug Delivery
Background:
- Ocular drug delivery faces significant biological and physiological barriers, limiting therapeutic efficacy.
- Gelatin, a Generally Regarded As Safe (GRAS) biomaterial, has potential for ocular applications but remains underexplored.
- Existing ocular drug delivery systems often struggle with poor bioavailability and short residence times.
Purpose of the Study:
- To review recent advancements in using gelatin-based micro- and nanoparticles for ocular drug delivery.
- To highlight the potential of gelatin as a safe and effective biomaterial for ophthalmic applications.
- To encourage further investigation into gelatin's utility in overcoming ocular drug delivery hurdles.
Main Methods:
- Literature review of studies employing gelatin micro- and nanoparticles for ocular delivery.
- Analysis of research focusing on formulation, characterization, and in vitro/in vivo performance.
- Synthesis of findings related to drug loading, release kinetics, and ocular tissue interaction.
Main Results:
- Gelatin micro- and nanoparticles demonstrate potential for enhanced ocular drug loading and controlled release.
- Studies show improved corneal penetration and prolonged retention of drugs delivered via gelatin systems.
- Gelatin-based nanoparticles exhibit good biocompatibility and safety profiles for ocular administration.
Conclusions:
- Gelatin micro- and nanoparticles represent a promising strategy for improving ocular drug delivery.
- Further research is warranted to fully exploit gelatin's potential in developing advanced ophthalmic formulations.
- Gelatin offers a safe and versatile platform for addressing the challenges in ocular drug administration.
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