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Cholangiocarcinoma in two siblings with emphysema and alpha-1-antitrypsin deficiency
D M Parham1, J R Paterson, A Gunn
1Department of Pathology, Ninewells Hospital and Medical School, Dundee.
The Quarterly Journal of Medicine
|April 1, 1989
Abstract:
Two siblings with homozygous ZZ alpha-1-antitrypsin deficiency were discovered to have primary liver tumours (both cholangiocarcinomas). This lends support to the view that alpha-1-antitrypsin deficiency plays a role in the development of some primary liver tumours.